A deeper understanding of AFib could lower risk

A deeper understanding of AFib could lower risk

First appeared on ScienceDaily.com

More than 2.5 million Americans are living with Atrial Fibrillation (AFib). AFib is an irregular heartbeat that can lead to blood clots, stroke, heart failure and other heart-related complications.

What doctors and researchers currently understand about treating AFib stems mainly from whether a patient has been diagnosed with the condition or not. University of Minnesota researchers are urging the medical community to take a closer look, specifically at AFib burden.

AFib burden refers to the amount of AFib that an individual has. The goal of the scientific statement published in the American Heart Association’s journal Circulation is to increase knowledge and awareness by healthcare professionals of effective, state-of-the-art science related to the causes, prevention, detection, management, and future research needs related to AFib burden.

“We hope to bring awareness to this concept of measuring the AFib burden and then to outline what we know about it,” said Lin Yee Chen, MD, MS, tenured associate professor, Department of Medicine at the University of Minnesota Medical School, “the hope then is to use that knowledge so more research can be done to fill in those gaps.”

AFib is associated with an elevated risk of stroke, and this statement also pushes for more research to refine risk classifications for stroke. Further understanding the relationship between AFib pattern or burden and stroke risk might result in deeper insights into stroke prevention.

“We could see an enormous benefit to our patient population once these standards are applied. And now is the time to do so,” said Chen.

Story Source: University of Minnesota Medical School. “A deeper understanding of AFib could lower risk.” ScienceDaily. ScienceDaily, 6 June 2018. <www.sciencedaily.com/releases/2018/06/180606143719.htm>.

Electrophysiological sign of cerebral infarction identified

Electrophysiological sign of cerebral infarction identified

A massive and extremely slow change in electrical potential is evidence of irreparable damage

First appeared on ScienceDaily.com

Researchers from Charité — Universitätsmedizin Berlin have analyzed the underlying electrophysiological indicators of subarachnoid hemorrhage, the second most common type of brain hemorrhage that can lead to ischemic stroke within a matter of days. Their findings, which have been published in the journal Brain, may lay the foundations for new stroke treatments.

Subarachnoid hemorrhage is a type of brain bleed that occurs in the area between the membranes surrounding the brain. Patients with subarachnoid hemorrhage can develop complications within approximately one week. Between one in three and one in four patients will develop symptoms of ischemic stroke, a type of stroke caused by an inadequate blood supply. This phenomenon occurs as the result of mechanisms triggered by the molecular breakdown products of the patient’s earlier hemorrhagic stroke. It sets off a wave of electrochemical depolarization, or ‘spreading depolarization’, within the brain tissue. Affected areas of the brain require large amounts of energy in order to restore normal conditions.

In healthy brains, this depolarization of nerve cells is linked to blood supply, meaning blood vessels widen in areas of the brain that are active. However, a subarachnoid hemorrhage may disrupt the signaling cascades between nerve cells and blood vessels, so that the depolarization of nerve cells causes extreme constriction of the blood vessels, which leads to spreading ischemia. Deprived of energy, the nerve cells are incapable of restoring normal electrochemical gradients. If depolarization persists for too long, affected nerve cells will begin to die off. Measurements of the electrical brain potential will then show an extreme and very gradual change , a process known as ‘negative ultraslow potential’, which is indicative of ‘terminal spreading depolarization’.

“Two months ago, we were able to show for the first time that terminal spreading polarization occurs in humans — namely in patients who had suffered cardiac arrest. Now we have been able to show that it also occurs in patients with cerebral infarctions after subarachnoid hemorrhage,” explains Prof. Dr. Jens Dreier of Charité’s Center for Stroke Research Berlin (CSB). Prof. Dreier and his team analyzed data from 11 patients, comparing their findings with results obtained from animal experiments. The waves of depolarization observed indicate disturbances of energy metabolism. The ‘negative ultraslow potential’ constitutes the electrophysiological correlate of infarction, and of tissue death due to an inadequate supply of blood.

Prof. Dreier emphasizes: “Measurements of spreading depolarization may prove as important to the development of interventions for patients with stroke, global ischemia and traumatic brain injury, as similar electrophysiological tools have proved in the past, in the areas of epilepsy or cardiology — because they make the underlying causes visible.”

Story Source: Charité – Universitätsmedizin Berlin. “Electrophysiological sign of cerebral infarction identified: A massive and extremely slow change in electrical potential is evidence of irreparable damage.” ScienceDaily. ScienceDaily, 29 May 2018. <www.sciencedaily.com/releases/2018/05/180529132142.htm>.

All stroke survivors have to have access to ongoing rehabilitation services for as long as required

All stroke survivors have to have access to ongoing rehabilitation services for as long as required

Written by Jelena Misita, SAFE Awareness and Advocacy Manager

Prof. Valery Feigin, photo credits: www.stroke.net.nz

I first met Prof. Valery Feigin in person in Gothenburg this May, when he visited SAFE stand at ESOC 2018. I knew him, of course, from the literature, with his name coming across many references. According to his official biography, this was hardly any wonder, as he had published over 600 research articles over his career and his publications have been cited over 30,000 times, within his prime research interest fields- prevention and management of stroke, epidemiology and traumatic brain injury.

Imagine my surprise when he suddenly appeared at a patient support organisation stand, shook my hand and said he’s started a website for patient support in New Zealand. I just had to tell him that in stroke world, he is nothing short of a celebrity and that we will be honoured to help him spread the news about his latest project. The project is in fact being realised through the New Zealand Stroke Education Trust, a charitable organisation based in New Zealand.

We set up an interview and I used the opportunity to ask him not only about his current project, but also about his view on the Stroke Action Plan for Europe 2018-2030, ICD-11 and how could these things lead to a real-life impact on stroke prevention, treatment and after-care. (more…)

Mice regrow brain tissue after stroke with bioengineered gel

Mice regrow brain tissue after stroke with bioengineered gel

Replacement neurons, blood vessels fill in stroke cavity; gel provides scaffolding

First appeared on ScienceDaily.com

In a first-of-its-kind finding, a new stroke-healing gel helped regrow neurons and blood vessels in mice with stroke-damaged brains, UCLA researchers report in the May 21 issue of Nature Materials.

“We tested this in laboratory mice to determine if it would repair the brain in a model of stroke, and lead to recovery,” said Dr. S. Thomas Carmichael, Professor and Chair of neurology at UCLA. “This study indicated that new brain tissue can be regenerated in what was previously just an inactive brain scar after stroke.”

The results suggest that such an approach may someday be a new therapy for stroke in people, said Dr. Tatiana Segura, a former Professor of Chemical and Biomolecular Engineering at UCLA who is now a professor at Duke University. Carmichael and Segura collaborated on the study.

The brain has a limited capacity for recovery after stroke and other diseases. Unlike some other organs in the body, such as the liver or skin, the brain does not regenerate new connections, blood vessels or new tissue structures. Tissue that dies in the brain from stroke is absorbed, leaving a cavity, devoid of blood vessels, neurons or axons, the thin nerve fibers that project from neurons.

To see if healthy tissue surrounding the cavity could be coaxed into healing the stroke injury, Segura engineered a gel to inject into the stroke cavity that thickens to mimic the properties of brain tissue, creating a scaffolding for new growth.

The gel is infused with molecules that stimulate blood vessel growth and suppress inflammation, since inflammation results in scars and impedes regrowth of functional tissue.

After 16 weeks, stroke cavities in mice contained regenerated brain tissue, including new neural networks — a result that had not been seen before. The mice with new neurons showed improved motor behavior, though the exact mechanism wasn’t clear.

“The new axons could actually be working,” said Segura. “Or the new tissue could be improving the performance of the surrounding, unharmed brain tissue.”

The gel was eventually absorbed by the body, leaving behind only new tissue.

This research was designed to explore recovery in acute stroke, or the period immediately following stroke — in mice, that is five days; in humans, that is two months. Next, Carmichael and Segura are determining if brain tissue can be regenerated in mice long after the stroke injury. More than 6 million Americans are living with the long-term outcomes of stroke, known as chronic stroke.

Story Source: University of California – Los Angeles. “Mice regrow brain tissue after stroke with bioengineered gel: Replacement neurons, blood vessels fill in stroke cavity; gel provides scaffolding.” ScienceDaily. ScienceDaily, 21 May 2018. <www.sciencedaily.com/releases/2018/05/180521131811.htm>.

Catalonia faces Stroke with the European tools

Catalonia faces Stroke with the European tools

Written by Maties Salom, Fundació Ictus Barcelona

Barcelona, 1st June 2018- The Fundació Ictus, a stroke support organisation from Barcelona, organised today a gathering  related to the challenges that stroke presents for all European countries. At this meeting, the Catalan Foundation introduced data on stroke in Catalonia, following the path opened by the Stroke Alliance for Europe with The Burden of Stroke Report, published in 2017. The conference “Catalunya i Europa davant l’ictus” (“Catalonia and Europe in front of the stroke“) was opened by SAFE President, Jon Barrick, and European Stroke Organisation Past President, Valeria Caso. The meeting convened more than 150 people with different professional backgrounds- medics, researchers, stroke survivors and their relatives.

Approximately 13.000 stroke patients get admitted in the Catalan hospitals every year. This condition’s incidence is almost 180 cases for every 100.000 people and mortality is 29,5/100.000. The conference faces issues in domains of research, primary prevention, stroke services organisation, acute stroke management, rehabilitation and life after stroke.

Speakers addressed all of these points in two round tables which helped build a complete overview of the situation with stroke in Europe and outlined a road map for all the countries over the next decade.

The meeting mainly focused on the stroke situation in Catalonia and presented the Catalan point of view of the Stroke Action Plan for Europe 2019-2030, recently presented in the European Parliament by ESO and SAFE. The Member of the European Parliament, Mr Ramon Tremosa, provided the institutional point of view of the discussed issues.

The neurologist from Barcelona, Mr Angel Chamorro, presentated the current state of stroke care in Catalonia, which is very good at the moment, but they are looking at the 2030 targets and striving for excellence.

Need to improve your advocacy skills? No problem- SSOFT Module 2 Launched

Need to improve your advocacy skills? No problem- SSOFT Module 2 Launched

Brussels, 31st May 2018 – The eLearning Module 2 of the Stroke Support Organisation Faculty Tool (SSOFT) is published today at the following address www.ssoft.info.

SSOFT’s second module focuses on the principles around advocacy, and is delivered in ten bite-sized sub-modules:

2.1 – Why does stroke care need to improve?
2.2 – What is advocacy?
2.3 – Unmet needs
2.4 – The value of evidence
2.5 – Decisions
2.6 – The health policy environment
2.7 – Identifying the decision makers
2.8 – Setting clear objectives
2.9 – Developing a strategy
2.10 – Your advocacy work

The module provides learners with a wealth of knowledge and includes videos, interactive content and activities. Learners will be able to work through the sub-modules at their own pace, earn rewards and share their progress on social media. (more…)

SAFE Angels patient information booklets in 13 languages now available for download

SAFE Angels patient information booklets in 13 languages now available for download

This May in 12 European countries: Spain, Serbia, Poland, Czech Republic, Latvia, Croatia, Macedonia, Greece, Ukraine, Georgia, Hungary and Turkey, stroke patients and their carers in a selected number of hospitals will be provided with information on stroke and important next steps on their path to recovery.

The patient-focused materials are made of five brochures, including a list of national, regional and local stroke support organisations, with their contact details, in order that patients and carers can access further support in the months and years following their stroke. The information provided in the brochures are kindly provided by the Stroke Association UK*and then translated to all project languages, applying the information standard procedure for the translation.

The original brochures are in English language and you can access their original content by following the links below:

Transient ischaemic attack
Next steps after stroke
Supporting a stroke survivor
When you have a stroke
How to reduce your risk

 

Please scroll down to see who is our member organisation in each project country and click on each photo to access the brochures in different languages.

Hungarian language – SAFE member Stroke Liga Nemzeti


Latvian language: Parsirdi.lv

 


Croatian language: Croatian Stroke Society (HDPMU)

 


Turkish language: BEYINDER

 


Polish language: Fundacja Udaru Mózgu

 


Spanish language: Federación Española del Ictus: FEI

 


Catalan language: Fundació Ictus

 


Macedonian language: Macedonian Stroke Association “Мозочен удар”

 


Georgian language: Mkurnali Foundation

 


Czech language: Organisations CEREBRUM and Sdružení pro rehabilitaci osob po cévní mozkové příhodě (Association for rehabilitation of persons after stroke)

 


Greek language: Hellenic alliance/action for stroke (HAAS)

 


Serbian language: Moždani udar – Stroke Association Serbia

 


Ukrainian language: School for Stroke Survivors (SSS) “Victory over the stroke”

 

*The Stroke Association UK: Copyright and disclaimer

The Stroke Association does not take responsibility for any errors that may appear in the translation, or the effects that an error may have. The original information contained in the publication should only be considered accurate until the published review date.

Please be aware that this information is not intended as a substitute for specialist professional advice tailored to your situation. We strive to ensure that the content we provide is accurate and up-to-date, but information can change over time. So far as is permitted by law, the Stroke Association does not accept any liability in relation to the use of the information in this publication, or any third-party information or websites included or referred to.

One World Voice for Stroke at the 71st World Health Assembly and UN High Level Meeting on NCDs

One World Voice for Stroke at the 71st World Health Assembly and UN High Level Meeting on NCDs

The text first appeared on the World Stroke Organisation blog

The World Stroke Organization leadership team and stroke survivors drawn from our membership network are in Geneva this week. They are contributing to critical health policy discussions taking place in and around the 71st World Health Assembly. In a packed programme they will be participating in sessions; contributing to partnership side-events; meeting with WHO technical leads and collaborating with our advocacy colleagues in the Non-Communicable Disease (NCD) arena to improve stroke prevention and equitable access to quality clinical care. (more…)

The Stroke Action Plan for Europe launched at 2nd EU Stroke Summit

The Stroke Action Plan for Europe launched at 2nd EU Stroke Summit

The Stroke Action Plan for Europe 2018-2030 was launched today in the EU Parliament within the 2nd Stroke Summit.

Last year, in May 2017, SAFE launched the Burden of Stroke Report which unveiled shocking disparities between and within European countries along the entire stroke care pathway. In order to take action, SAFE and the European Stroke Organisation (ESO) decided to formalise their partnership which has led, after extensive consultation and tireless work, to the creation of the Stroke Action Plan for Europe 2018-2030.

This document sets important targets covering seven key pillars, from primary prevention to life after stroke. The report was launched today at the 2nd Stroke Summit in the European Parliament in front of around 70 key stakeholders including patients, healthcare professionals and policy-makers. The event was co-hosted by MEP Elena Gentile (S&D, IT), who showed her support to stroke survivors and stroke-related issues across Europe.

All the speakers welcomed the Stroke Action Plan and saluted the effort made by SAFE and ESO in making the Stroke Action Plan for Europe possible. It provides a clear road map and outlines recommendations and targets for 2030 so that all relevant stakeholders take action to improve the stroke care pathway and reverse the current trends.

Currently, an increase of 34% in the absolute number of strokes is expected by 2035 in Europe, along with a 45% increase in the number of stroke deaths, and a 25% increase in the number of survivors living with the long-lasting effects of stroke. Action needs to be taken to prevent stroke more efficiently, provide timely and adequate treatment and rehabilitation to those who need it, and last but not the least, to improve the lives of stroke survivors and their families across Europe by providing the right level of support in their Life After Stroke. (more…)