Genetic variants may influence poststroke recovery

Genetic variants may influence poststroke recovery

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Our genes may have a bearing not only on our stroke risk, but probably also on how well we recover after stroke. For the first time, in international collaboration, scientists at the University of Gothenburg and elsewhere have identified common genetic variants that are associated with outcome after ischemic stroke.

The study, a meta-analysis of 12 international stroke studies, was led by research groups at two Swedish universities: Gothenburg and Lund. The study comprised more than 6,000 patients with ischemic stroke, the most common form of stroke, in which a blood clot causes a lack of oxygen in a region of the brain. Stroke can also be caused by a hemorrhage in the brain.

For the study, the patients were divided into two groups depending on their outcome at three months after ischemic stroke. One group was composed of people who had not survived and those who were dependent on help from others to cope with activities of daily living.

Those assigned to the second group were, three months after their stroke onset, able to cope unaided. By comparing analyses of the patients’ genomes, the researchers were able to find several different genetic variants that appear to have played a part in the patients’ outcomes.

“One of the common genetic variants we found was significant — that is, clearly associated with a worse outcome in the large volumes of data we were able to access,” says Annie Pedersen, a PhD student at Sahlgrenska Academy, University of Gothenburg, one of the lead authors of the study.

The genetic variant identified can be linked to another gene that is part of a major process involved in brain plasticity, which is the nerve cells’ ability to adapt and take over functions when other nerve cells in the brain die.

The study took into account several other factors — age, sex and the extent of the patient’s brain damage — that can also affect outcome after stroke. After adjustment for these factors, the association remained between the genetic variant and elevated risk of being in the group of patients who still, three months after the stroke onset, were unable to manage without assistance.

“Even if two patients seem to have the same prospects of recovering, their outcomes can be different. Studies on animals have indicated that there are genes that may contribute to the explanation, and we’ve now found support for them in humans as well,” Pedersen says.

Our limited knowledge of why some patients recover well while others incur lasting functional impairments after the same type of stroke has made it difficult to develop new treatment methods, thinks Professor Christina Jern of Sahlgrenska Academy, who ran the study in collaboration with Professor Arne Lindgren of Lund University.

“In the long run we hope the research may enable us to identify new targets for medication that might help to improve poststroke outcome, but there’s a lot of research to be done before we get there,” Jern says.

You can read the full article here.

Stroke risk drops in both black and white older adults

Stroke risk drops in both black and white older adults

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Recent reductions in hospitalization and death due to stroke extend to both black and white Medicare beneficiaries, reports a study in the April issue of Medical Care.

The reductions in mortality after initial stroke have been even greater in black Medicare patients, according to the new research by Margaret C. Fang, MD, MPH, of the University of California, San Francisco, and colleagues. Dr. Fang comments,” Despite these promising trends, our study also found that black men and women continue to be at higher risk for stroke than white patients.”

Stroke Risks Decline Over 25 Years — Trends Linked to Improving Risk Factors

Using Medicare data from 1988 to 2013, the researchers analyzed trends in hospitalization and mortality after an initial stroke in black or white men and women aged 65 or older. The study included more than 1 million hospitalizations for ischemic stroke, caused by blockage or narrowing of the brain blood vessels; and nearly 150,000 hospitalizations for hemorrhagic stroke, caused by bleeding into or around the brain.

Over the 25-year study period, hospitalizations for stroke decreased for both black and white patients. Adjusted for age, ischemic stroke risk decreased from 1,185 to 551 per 100,000 Medicare beneficiaries among black men and from 932 to 407 per 100,000 among white men. Risk fell from 1,222 to 641 per 100,000 for black women and from 892 to 466 per 100,000 for white women.

Mortality after ischemic stroke also fell, with greater reductions in black patients. Risk of death within 30 days after ischemic stroke decreased from approximately 16 to 8 percent in black men and from 16 to 12 percent in white men. Ischemic stroke mortality declined from about 14 to 9 percent in black women versus 16 to 15 percent in white women.

Read the full article here.

Five Ways of Fighting Depression

Five Ways of Fighting Depression

Author: Cornelius J Johnson

When you’re battling depression it’s difficult not to just let the pills do the work and hope for the best. As any good mental health professional will tell you, combating the symptoms of depression can take some self-governance and work. But when our mind is working against us at these times, where do we focus our attention?

Here are five simple areas to focus on in order to reduce the impact of depression.


When suffering from depressive thought patterns, sometimes we are prone to staying in bed for as long as possible. We take ourselves out of the equation and enjoy the warmth and comfort of the bed. But that doesn’t necessarily mean we get good rest. Often it means lying in bed worrying or thinking about things we cannot control.

“We should try view our bed as a vehicle for sleep, rather than a retreat from the world,” writes William Cosgrove, an author at Researchpapersuk and LastMinuteWriting. “It’s important that we foster a routine for ourselves of going to bed at a reasonable hour, and waking up having had a good nights sleep.”


Depression can have varied effects on how we use or view food. For some, the thought of eating can make us nauseous, and for others, we seem unable to get enough. When going through depressive periods we may either eat one particular kind of food or binge on snacks and junk food.

This fluctuation in our diets can have radical effects on our state of mind. The more we randomize our intake of nutrients the more likely it is that we’ll find ourselves in a bad place. Regular, healthy eating is vital to a good state of mind. If you face depression, keep motivated to maintain a strong routine of eating healthy food.


If you’re suffering from depression, the last thing you want to do is go out to the gym. Depression can be linked to body image or how we interact socially. As the gym combines both of these elements, it is understandable that those who suffer from depression aren’t likely to hit the gym any time soon. But this doesn’t mean you should abandon exercise totally.

Exercise is a great way of releasing endorphins. Many who suffer from depression take up solo activities, such as long distance running, walking or cycling. These activities offer us an opportunity to zone our minds on the simple act of physical movement rather than the abstract thoughts that come with depression.


Depression is a lonely state of being, and it can be tempting to fuel that loneliness by refusing to inflict on others. We get caught up with the notion that we are no fun to be around when we are depressed. It’s important to remember that our good friends are able to support us at these times.

As a society, people are becoming more open and honest about mental health, and those who suffer from depression should no longer feel they have to be secretive about it. Explain to your close circle the issue you are facing and you’ll soon find that you have allies to help you fight your corner.

Express yourself

“History is full of people who have turned depression to their advantage,” says Miranda Rhodes, a regular contributor to Draftbeyond and Writinity. “20th-century writers were often prone to depressive or anxious states. Though you need not expect yourself to write ‘A Farewell to Arms’ or ‘The Bell Jar’, writing or painting are excellent ways of channeling your depression into something beautiful.“

In getting our depression out into something we can read or view, we are able to objectify it and analyze it without being too close to it.

Cornelius J Johnson specializes in marketing and different aspects of entrepreneurship. He writes on a variety of subjects such as finance and marketing as well as lifestyle and personal development and is a regular contributor to Lucky Assignments and Gum Essays, academic writing websites.

New ACC/AHA guidance for preventing heart disease, stroke released

New ACC/AHA guidance for preventing heart disease, stroke released

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The choices we make every day can have a lasting effect on our heart and vascular health. Adopting a heart healthy eating plan, getting more exercise, avoiding tobacco and managing known risk factors are among the key recommendations in the 2019 Primary Prevention of Cardiovascular Disease guideline from the American College of Cardiology (ACC) and the American Heart Association (AHA). Also, it is recommended that aspirin should only rarely be used to help prevent heart attacks and stroke in people without known cardiovascular disease.

The guideline, presented today at ACC’s 68th Annual Scientific Session, offers comprehensive but practical recommendations for preventing cardiovascular disease, which remains the leading cause of death for both men and women in the United States. Nearly 1 out of 3 deaths in the U.S. is due to cardiovascular disease.

“The most important way to prevent cardiovascular disease, whether it’s a build-up of plaque in the arteries, heart attack, stroke, heart failure or issues with how the heart contracts and pumps blood to the rest of the body, is by adopting heart healthy habits and to do so over one’s lifetime,” said Roger S. Blumenthal, MD, co-chair of the 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease and the Kenneth Jay Pollin Professor of Cardiology at Johns Hopkins Medicine. “More than 80 percent of all cardiovascular events are preventable through lifestyle changes, yet we often fall short in terms of implementing these strategies and controlling other risk factors.”

Read the full article here.

Researchers explore stroke’s effects on microbiome

Researchers explore stroke’s effects on microbiome

First published on

Tumult in the bacterial community that occupies your gut — known as your microbiome — doesn’t just cause indigestion. For people recovering from a stroke, it may influence how they get better.

A recent study by Allison Brichacek and Candice Brown, researchers in the West Virginia University School of Medicine, suggests that stroke patients’ microbiomes — and even the structure of their guts — may still be out of kilter a month after the stroke has passed.

“We’re interested in the gut-brain axis — how the gut influences the brain and vice versa,” said Brichacek, a doctoral student in the immunology and microbial pathogenesis graduate program. She presented her findings at the International Stroke Conference in February.

Previous studies indicated the immediate effects a stroke can have on someone’s microbiome, but they didn’t explore whether these effects lingered. To find out, Brichacek, Brown and their colleagues — including Sophia Kenney, an undergraduate majoring in immunology and medical microbiology, and Stan Benkovic, a researcher in Brown’s lab — induced a stroke in animal models. Other models — the control group — didn’t have a stroke. The researchers compared the two groups’ microbiomes three days, 14 days and 28 days post-stroke. They also scrutinized their intestines for microscopic disparities.

Bacterial friend or foe?

One of the researchers’ discoveries was that a certain family of bacteria — Bifidobacteriaceae — was less prominent in post-stroke models than in healthy ones both 14 and 28 days out. If the name of the family sounds familiar, that’s probably because Bifidobacterium — a genus within the Bifidobacteriaceae family — is a common ingredient in yogurt and probiotics. These bacteria are known for supporting digestive health and may be associated with better outcomes in stroke patients.

Read the full article here.

#BrainLifeGoals: Brain Awareness Week 2019 starts now

#BrainLifeGoals: Brain Awareness Week 2019 starts now

Sharing #LifeGoals has become a popular trend on social media. A campaign from the European Federation of Neurological Associations [EFNA] and supported by many organisations across Europe will put a new spin on the trend by instead seeing patient advocates and supporters share their #BrainLifeGoals.
The #BrainLifeGoals campaign will raise awareness of the impact of neurological diseases by exploring the dreams and aspirations of those living with a brain disorder.

You can find out more about the campaign at and by following the #BrainLifeGoals hashtag on social media.