Mar 13, 2018
Published first on ScienceDaily
A new study has found that people with dengue fever have a higher risk of stroke, especially in the first 2 months following infection. The study is published in CMAJ (Canadian Medical Association Journal).
“Clinicians in dengue-endemic areas should be aware of this association, especially for patients with dengue who have neurologic deficits or for patients with stroke who have unexplained fever,” writes Dr. Chia-Hung Kao, Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan, with coauthors.
Dengue is a mosquito-borne viral infection that infects at least 100 million people every year around the world, with about 4 billion people at risk of the illness, which includes dengue hemorrhagic fever that can lead to spontaneous bleeding, organ failure and death. It is found in many countries in South and Southeast Asia, Africa, South America, the Caribbean, in the United States and more. (more…)
Mar 13, 2018
Published first on ScienceDaily
Doctors caring for severe stroke patients need to take account of their psychological needs and help prepare families for the possibility that they may not recover, a study suggests.
Patients and their families experience debilitating feelings of loss and uncertainty following a major stroke that impact on their quality of life, the findings show.
The results, from repeat interviews carried out over six months, also suggest that healthcare professionals should not shy away from sensitive discussions about death.
The study by the Universities of Edinburgh and Glasgow followed patients in Scotland over the course of a year following a severe form of stroke. Healthcare staff and family carers were also interviewed. (more…)
Mar 13, 2018
Published first on ScienceDaily
New research published in the journal Nature for the first time reveals the atomic structure of a key molecular component of the nervous system.
Scientists at OHSU used advanced imaging techniques to ascertain the resting state of an acid-sensing ion channel. “They are really important ion channels that are spread throughout the body,” said senior author Eric Gouaux, Ph.D., senior scientist with the OHSU Vollum Institute and an investigator with the Howard Hughes Medical Institute. “People have pursued them as targets for stroke therapies, and they clearly have important roles in pain transduction.” (more…)
Mar 13, 2018
Published first on ScienceDaily
Notoriously remembered as a major pharmaceutical scandal approximately 60 years ago, thalidomide caused severe birth defects since many pregnant women took the drug as a remedy for their morning sickness. In recent years, however, thalidomide and its derivatives have been widely used to treat hematologic malignancies such as multiple myeloma.
Further, evidence suggests that it also has a neuroprotective effect, reducing both oxidative stress and inflammatory response, but the exact molecular mechanisms of thalidomide on the brain were unknown.
To investigate, scientists at Waseda University and Tokyo University of Pharmacy and Life Sciences studied thalidomide’s target protein, cereblon (CRBN), and its binding protein, AMP-activated protein kinase (AMPK), which plays an important role in maintaining intracellular energy homeostasis in the brain. Through their study, they revealed that thalidomide inhibits the activity of AMPK via CRBN under oxidative stress and suppresses nerve cell death. (more…)
Mar 13, 2018
The webinar will kick-off the State of the Art on how Stroke treatment can be improved by focusing on the organization of the Systems of Care and in the In-Hospital Organization. (more…)
