SVDs@Target


An international consortium of mostly European investigators has launched a major collaborative research program to uncover mechanisms and pathways in different forms of small vessel disease.

Stroke and dementia rank among the most pressing health issues in Europe. Cerebral small vessel diseases (SVDs) have emerged as a central link between these two major co-morbidities. SVDs account for more than 30% of strokes and at least 40% of dementia cases. They encounter multiple distinct diseases that can be separated based on their underlying genetic defects, risk factors, and clinical presentations. Despite this profound impact on human health, there are no treatments with proven efficacy against SVDs.

The new network “Small vessel diseases in a mechanistic perspective: Targets for Intervention in Stroke and Dementia(SVDs@target)” is funded through the European Union’s Horizon 2020 research and innovation programme and brings together top scientists with a wide range of complementary expertise.

The project also includes 3 studies with stroke patients. They are:

ZOOM@SVDs, a high-resolution imaging study to look at vascular function and brain  damage

INVESTIGATE-SVDs, an imaging study to assess the blood/brain barrier and vascular function,

TREAT-SVDs, testing the effects of different blood pressure lowering agents on vascular function in patients with distinct SVDs

SVDs@target is a project consisting of preclinical work and clinical studies. With the three clinical studies involved in this project, we aim to increase our knowledge on small vessel diseases. The study designs were presented for the first time at the ESOC 2017 during the poster presentation.

Common features of all three clinical studies

We aim to include patients with sporadic small vessels disease clinically presenting with a lacunar stroke or vascular cognitive impairment. In addition, we will include CADASIL patients suffering from a genetic form of small vessel disease. In all our clinical studies, we will measure the function of the small blood vessels in the brain with a so called hypercapnic challenge. Participants will inhale medical grade air and a CO2-air-mixture. CO2 is a physiological stimulus for blood vessels to dilate. This will be measured using the BOLD MRI sequence.

Zoom@SVDs

We aim to advance our knowledge of why small vessel disease develops by using one of the strongest MRI scanners currently available.

Study type: case-control-study

Number of participants: 60 patients with sporadic small vessel disease, 15 CADASIL patients (genetic small vessel disease), 45 healthy controls (age- and sex-matched)

Study sites: Utrecht (NL) as coordinating centre; Munich (DE)
Study duration for each study participant: 8 days with a follow-up after 2 years
Status: recruiting
Flyer: available in German and in English
Further information will come soon.

INVESTIGATE-SVDs

We aim to use newly developed advanced MRI brain scans to measure how well the small blood vessels are working to prevent leakage of damaging inflammatory cells into the brain tissue and ensure enough blood gets to the brain when it is needed.

Study type: observational study

Number of participants: 45 patients with sporadic small vessel disease, 30 CADASIL patients (genetic small vessel disease)

Study sites: Edinburgh (UK) as coordinating centre; Maastricht (NL); Munich (DE)

Study duration for each study participant: 8 days with a telephone follow-up after 1 year (follow-up will not be included in Maastricht)

Status: starting soon (June 2017)

Flyer: available in English, German and Dutch

TREAT-SVDs

(EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases)

High blood pressure is one of the most important risk factors for developing small vessel disease but currently it is not clear which blood pressure lowering drugs are best at improving small blood vessel function. We propose that the function of the small microvessels in the brain can be influenced by medication.

Study type: clinical interventional trial comparing three blood pressure medications in small vessel disease

Number of participants: 75 patients with sporadic small vessel disease, 30 CADASIL patients (genetic small vessel disease)

Study sites: Munich (DE) as coordinating centre; Oxford (UK); Edinburgh (UK); Maastricht (NL); Utrecht (NL)

Study duration for each study participant: 14 weeks

Status: not yet recruiting

Flyer: available in English, German and Dutch